Viral infections and molecular mimicry in type 1 diabetes
نویسندگان
چکیده
منابع مشابه
Viral Infections and their Role in Autoimmune Diseases, with Emphasis on Mechanisms and Molecular Interactions
Introduction: The exact cause of most autoimmune diseases is still unknown; however, several factors play a role in causing or exacerbating autoimmune reactions. In addition to environmental factors such as bacterial, parasitic, fungal and viral infections, factors such as genetic characteristics and lifestyle are also included. Infections caused by viruses usually trigger a strong immune respo...
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Gram-negative bacteria Helicobacter pylori (H. pylori) colonize gastric mucosa in humans and increase the risk of serious diseases such as gastric and duodenal ulcers, stomach cancers and mucosa associated lymphoid tissue lymphoma. The role of H. pylori infection in the pathogenesis of several extragastric diseases has been suggested including immune thrombocytopenic purpura, iron deficiency an...
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Viral infection is sometimes associated with the initiation or exacerbation of autoimmune disease, although the underlying mechanisms remain unclear. One proposed mechanism is that viral determinants that mimic host antigens trigger self-reactive T cell clones to destroy host tissue. An epitope expressed by a coat protein of herpes simplex virus-type 1 (HSV-1) KOS strain has now been shown to b...
متن کاملVirus infections in type 1 diabetes.
The precise etiology of type 1 diabetes (T1D) is still unknown, but viruses have long been suggested as a potential environmental trigger for the disease. However, despite decades of research, the body of evidence supporting a relationship between viral infections and initiation or acceleration of islet autoimmunity remains largely circumstantial. The most robust association with viruses and T1...
متن کاملMolecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.
Virus infections and autoimmune disease have long been linked. These infections often precede the occurrence of inflammation in the target organ. Several mechanisms often used to explain the association of autoimmunity and virus infection are molecular mimicry, bystander activation (with or without epitope spreading), and viral persistence. These mechanisms have been used separately or in vario...
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ژورنال
عنوان ژورنال: APMIS
سال: 2012
ISSN: 0903-4641
DOI: 10.1111/apm.12011